Cystic acne is a very large type of pimple and Nodular acne is a smaller, red pimple. Large and usually painful nodules are inflamed, pus-filled lesions lodged deep within the skin. Nodules develop when the contents of a comedo (whitehead or blackhead) have spilled into the surrounding skin and the local immune system responds, producing pus. The most severe form of acne lesion nodules may persist for weeks or months, their contents hardening into a deep cyst. Both nodules and cysts often leave deep scars.
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